91
Views
21
CrossRef citations to date
0
Altmetric
Original Article

How to establish glomerular filtration rate in children

Pages 46-51 | Published online: 08 Jul 2009
 

Abstract

The availability of a world‐wide standard for creatinine is an important milestone improving glomerular filtration rate (GFR) estimations in adults. However, an unacceptable inter‐laboratory variation is still observed which is mainly due to differences in calibration, especially in children and infants, where reference ranges for serum and plasma creatinine are low. Compensating calibration in Jaffe assays to IDMS standards results in an underestimation of serum or plasma creatinine due to the lower reference values for total protein in younger children. Alternatively, using enzymatic assays emphasizes the relative proportion of tubular secretion of creatinine, which renders serum or plasma creatinine less suited as a GFR marker in children. Updating the currently used estimation formulas for calculating creatinine clearance and GFR is far from easy. Low molecular mass marker proteins such as cystatin C and beta trace protein can be regarded as an attractive practical alternative for assessing GFR since they require determination only in serum or plasma and are better suited in the blind range of creatinine.

Acknowledgement

Dr. Birgitte Wuyts is thanked for helpful discussions.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 200.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.