Effects of parathyroidectomy on bone metabolism in haemodialysis patients with secondary hyperparathyroidism

Abstract

Objective: To evaluate the outcome of bone metabolism and bone mineral density (BMD) in haemodialysis patients after parathyroidectomy (PTX).

Methods: A total of 31 haemodialysis patients with secondary hyperparathyroidism (SHPT) were treated with PTX. BMD of lumbar spine (LS) and femoral neck (FN) was determined by dual energy X-ray absorptiometry.

Results: Parathyroidectomy ledds to significant decrease of serum β-crosslaps (β-CTX), osteocalcin (OC) and procollagen type I amino-terminal propeptide (PINP) while serum sclerostin (SOST) increased after surgery. BMD was markedly improved in both LS and FN after PTX. Z-scores analysis further confirmed that PTX significantly benefited bone metabolism in haemodialysis patients, which well correlated with the improvement of serum iPTH and OC.

Conclusions: Parathyroidectomy leads to significant improvement of serum OC, PINP, β-CTX and SOST, which may beneficially modify calcium–phosphorus metabolism and BMD in haemodialysis patients with SHPT.

Keywords:

• Chronic kidney disease
• mineral bone disease
• parathyroidectomy
• secondary hyperparathyroidism
• haemodialysis

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study is supported by Central laboratory special fund Tongzhou District science and Technology Committee (KJ2017CX036-13).