Hepatic Wash-out Curves of ⁸⁵Kr and ¹³³Xe after Retrograde Hepatic Venous Injections in Patients with Infectious Hepatitis and in Controls

Abstract

In 8 patients with infectious hepatitis and in 10 controls the disappearance rates of ⁸⁵Kr and ¹³³Xe were measured externally after labeling hepatic tissue by retrograde simultaneous hepatic venous injections of the isotopes. As xenon has a higher affinity for fat than has krypton, the quotient between the halftime for ⁸⁵Kr and for ¹³³Xe could be used for calculation of hepatic fat content as well as the partition coefficients of the isotopes between hepatic tissue and blood. The estimated hepatic fat content was significantly higher in the patients than in the controls, 5.8 versus 3.6 per cent. The calculated partition coefficients in the controls were 1.09 and 1.13, respectively, for krypton and xenon. The corresponding values in the patients were significantly higher, 1.25 and 1.41, respectively. The clearances of the isotopes seemed to overestimate the average perfusion coefficient by 25 per cent, as judged from total hepatic blood flows and expected liver weights. A possible explanation might be local hyperemia in the injected areas. The present data indicate that this method can be used to estimate partition coefficients and hepatic fat content.

Key Words:

• Clearance
• hepatic fat content
• hepatitis
• infectious
• krypton
• normal men
• partition coefficients
• xenon