Parenteral nutrition including amino acids fails to increase creatinine clearance in catabolic patients

Abstract

A 70% increase in creatinine clearance (C_cr) has been reported previously in patients receiving parenteral nutrition (P.N.) with amino acids compared with P.N. without amino acids.

We have investigated 10 male catabolic patients who got P.N. with and without amino acid solution. Twelve-hour C_cr was done on two consecutive days during infusion of P.N. On the second day 1000 ml of isotonic saline was replaced by 1000 ml of amino acid solution (Vamin^® 14g N/1).

We found a statistically non-significant increase in C_cr (median: 1.6%, 95% confidence interval: -8.5% to 11.3%).

In conclusion, no clinically important change in C_cr occurs in catabolic patients during P.N. with amino acids.

Key Words:

• glomerular filtration rate
• parenteral feeding