The Gastrointestinal Absorption and the Excretion of H³-Butylscopolamine (Hyoscine Butylbromide) in Man

Abstract

Hellström, K., Rosén, A. & Söderlund, K. 1970. The Gastrointestinal Absorption and the Excretion of H³-Butylscopolamine (Hyoscine Butylbromide) in Man. Scand. J. Gastroent. 5, 585-592.

H³-butylscopolamine (hyoscine butylbromide) in doses of 50-100 mg and an unabsorbable marker (polyethylene glycol, PEG) were administered orally or by intra-intestinal infusion to 6 healthy subjects. By comparison of the amount of radioactivity per mg PEG in intestinal aspirates and in the test solution, it appeared that only a small percentage of administered tritium was absorbed during passage through the upper small intestine. No radioactivity could be detected in plasma. The urinary and fecal excretion of label amounted to 2 and 90 per cent of the given dose, respectively. Electrophoretic analyses of small intestinal contents showed no evidence of a metabolic change of the drug. After intravenous injection of 8 mg butylscopolamine to 1 subject, 42 per cent of the administered radioactivity was eliminated in the urine and 37 per cent in the feces.

Key-words::

• Drug therapy
• gastrointestinal agents
• intestinal absorption
• parasympatholytics
• tropanes