Taurocholate Metabolism in Patients with Small Intestinal Stagnant Loops

Abstract

Arnesjö, B., Ståhl, E., Sörbris, R. & Kock, N-G. Taurocholate metabolism in patients with intestinal stagnant loops. Scand. J. Gastroent. 1974, 9, 579–585.

Eleven cases, three with duodenal or jejunal diverticula without malabsorption, four with proximal stagnant loops and malabsorption, and four with distal stagnant loops and slight malabsorption were given tracer doses of ³⁵S-tauro-7-³H-cholate, and duodenal aspirates obtained during the subsequent 7 days were examined. Specific radioactivities of both isotopes were determined. Those patients having proximal blind loops without malabsorption had a taurocholate metabolism no different from healthy individuals. All patients with stagnant loop syndromes regardless of location of the lesions had diminshed taurocholate pool sizes, increased turnover of taurocholate, increased taurocholate synthesis, and increased rate of deconjugation and - provided that an intact colon was present - increased rate of 7-α-dehydrox-ylation. In four cases the disappearance of the administered isotopes was too rapid to allow accurate estimation of their taurocholate metabolism. In four patients with ileostomy-reservoir after panproctocolectomy, low duodenal bile acid concentrations with virtually no deoxycholate were found, whereas the G/T bile acid molar ratios were within the normal range. The remainder of the patients with stagnant loop syndromes had normal duodenal bile acid concentrations, increased G/T molar ratios, and normal 30H/20H molar ratios.

Key-words::

• Bile salts
• blind loops
• deconjugation
• 7-α-dehydroxylation
• elimination
• intestinal stenoses
• relative concentrations
• stagnant loops
• taurocholate