Taurocholate Metabolism after Truncal Vagotomy and Pyloroplasty or Antral Resection

Abstract

Arnesjö, B. & Ståhl, E. Taurocholate metabolism after truncal vagotomy and pyloroplasty or antral resection. Scand. J. Gastroent. 1974, 9, 601–606.

Tracer doses of doubly labelled taurocholate ³⁵S-tauro-7-H-cholate were given to 8 patients who had undergone truncal vagotomy and pyloroplasty or antral resection because of benign duodenal ulcer. Duodenal aspirates from the subsequent 7 days were examined. Results were compared to those obtained in healthy individuals. Taurocholate pool size was 0.59 ±0.18 g, which is less than that of the healthy group. Half life of the taurocholate pool was 1.2 ± 0.5 days, which was lower than in controls. The mean daily production of taurocholate was 0.29 ± 0.05 g, which was no different from that of the control group. The average fractional deconjugation rate was 0.19 ± 0.06, and the 7-α-dehydroxylation rate was 14.0 ± 2.5 % day^-1, both increased compared to healthy individuals. The alterations of the taurocholate metabolism might speak in favour of a bacterial overgrowth in the small intestine.

Key-words::

• Antral resection
• deconjugation
• 7-α-dehydroxylation
• pyloroplasty
• taurocholate
• truncal vagotomy