Abstract
Nylander, B. & Andersson, S. Gastric secretory inhibition by two 16-methyl-ated analogs of prostaglandin E2 given intragastrically to patients with duodenal ulcer disease. Scand. J. Gastroent. 1975, 10, 217-220.
The effects of two methylated analogs of prostaglandin E., (PGE.,), namely 16,16-dimethyl PGE;, and its methyl ester, on gastric acid and pepsin secretion have been studied in 5 ulcer patients. Both analogs produced significant inhibition of acid secretion in a dose-dependent fashion, but the effect was less pronounced than the inhibition found in a group of healthy volunteers, and it was necessary to give 140 μg of each analog to reach about the EDfj0. The mean values of pepsin output and pepsin concentration were decreased following administration of PGE2, but the individual results varied.