Effect of Resection of Antrum and Duodenal Bulb on Sham-feeding-induced Inhibition of Canine Gastric Secretion

Abstract

In dogs with Heidenhain pouches and oesophageal and gastric fistulae, sham feeding inhibited pentagastrin-stimulated Heidenhain pouch acid output. Resection of the antrum and the duodenal bulb reduced or abolished the inhibitory effect of sham feeding in most dogs when the acid of the main stomach was diverted through the gastric cannula. The present results are consistent with the hypothesis that sham feeding inhibits Heidenhain pouch acid secretion at least partly by inducing a vagal release of an inhibitory hormone. The results suggest that this hormone is released from the antrum and the duodenal bulb.

Key-words:

• Antrum
• duodenal bulb
• gastrin
• sham feeding
• stomach
• vagus