Renal Extraction of Endogenous Gastrin in Patients with Normal Renal Function

Abstract

Renal extraction of gastrin in patients with normal clearance of inulin and p-aminohippuric acid was assessed by gastrin radioimmunoassay. In 23 fasting patients there was no significant difference in arterial gastrin (37.7 pg/ml serum ±25.1 S.D.) and the renal vein gastrin (35.9 ± 24.6), resulting in a renal extraction ratio for gastrin not significantly different from zero (p>0.5). The results in three patients indicated no extraction of gastrin for two consecutive periods after a protein-rich meal.

Key-words:

• Gastrin
• metabolism
• kidney