Mallory Weiss syndrome is not associated with hiatal hernia: a matched case–control study

Abstract

Background/objective: Hiatal hernia is considered to be a predisposing factor to develop Mallory-Weiss Syndrome (MWS). No large case–control studies verifying this hypothesis have been conducted.

Methods: We reviewed all esophagogastroduodenoscopies with findings of MWS (n = 2342) in a national database and compared with age and gender-matched controls (n = 9368). Demographics, endoscopic characteristics and presence of a hiatal hernia were compared between both groups. Average age was 56.7 ± 18.6 years, and 72.4% were male.

Results: Hiatal hernia was more common in controls, and no significant difference was seen in a multivariate analysis.

Conclusion: Dynamic changes inducing mucosal tension are more relevant determinants to develop MWS than gastro-esophageal junction location alone.

Keywords:

• Mallory Weiss
• gastrointestinal bleeding
• hiatal hernia
• esophagus

Acknowledgements

The data from the CORI reported here were supplied by the NIDDK Central Repositories. This manuscript was not prepared in collaboration with the CORI group and does not necessarily reflect the opinions or views of the CORI group, the NIDDK Central Repositories, or the NIDDK.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

The CORI v3 Database is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). D. A. Sussman is supported in part by grants from the Center for AIDS Research (CFAR) at the University of Miami – Miller School of Medicine, funded by a grant from the National Institutes of Health (P30AI073961), American Cancer Society and the Florida Department of Health.