Abdominal paracentesis drainage improves tolerance of enteral nutrition in acute pancreatitis: a randomized controlled trial

Abstract

Objective: The objective of this study is to determine whether abdominal paracentesis drainage (APD) could improve the administration of enteral nutrition (EN) in acute pancreatitis.

Methods: Between January 2015 and April 2016, a total of 161 acute pancreatitis patients were enrolled and randomly assigned to either the APD group or the non-APD group. Several indexes associated with the administration of EN, including the gastroparesis cardinal symptom index (GCSI), the incidence of gastrointestinal adverse events, and the clinical outcomes, were recorded.

Results: The mean GCSI scores were 13.6 ± 2.1 before randomization and 7.1 ± 2.3 after a week in the APD group. These scores were 13.9 ± 2.4 and 9.7 ± 1.9 in the non-APD group. The incidences of gastrointestinal adverse events in the two groups were similar (p > .05), except for diarrhea. However, the patients in the APD group spent less time achieving the nutrition target (25 per kilogram of body weight per day) and fully tolerated the oral diet (p < .05). Additionally, the clinical outcomes of the APD group were better compared with those of the non-APD group.

Conclusion: APD can improve the administration of EN in acute pancreatitis. Given the positive effect of EN on clinical outcomes, this phenomenon possibly explains why APD could improve the clinical outcomes of acute pancreatitis patients in some aspects.

Keywords:

• Abdominal paracentesis drainage
• enteral nutrition
• acute pancreatitis
• randomized controlled trial

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. The study was supported by Pancreatic Injury and Repair Key Laboratory of Sichuan Province (2016JPT0034), National Natural Science Foundation of China (81500409), and Science and Technology Development Plan of Sichuan Province (2016JY0023).

Additional information

Funding

The study was supported by Pancreatic Injury and Repair Key Laboratory of Sichuan Province (2016JPT0034), National Natural Science Foundation of China (81500409), and Science and Technology Development Plan of Sichuan Province (2016JY0023).