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Scandinavian Journal of Gastroenterology Volume 55, 2020 - Issue 2
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Original Article

Pentoxifylline has favorable preventive effects on experimental chronic pancreatitis model

Muhammed YildirimDepartment of Internal Medicine, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey; ORCID Iconhttp://orcid.org/0000-0002-3482-7167
ORCID Icon,
Mustafa KaplanDepartment of Internal Medicine, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey; ORCID Iconhttp://orcid.org/0000-0002-0354-4762
ORCID Icon,
Tolga DuzenliDepartment of Gastroenterology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6279-1018
ORCID Icon,
Alpaslan TanogluDepartment of Gastroenterology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey; ORCID Iconhttp://orcid.org/0000-0002-7477-6640
ORCID Icon,
Zafer KucukodaciDepartment of Pathology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, TurkeyORCID Iconhttp://orcid.org/0000-0001-5170-9093
ORCID Icon,
Yesim Onal TastanDepartment of Internal Medicine, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey; ORCID Iconhttp://orcid.org/0000-0003-0034-8325
ORCID Icon,
Basak Cakir GuneyDepartment of Internal Medicine, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey; ORCID Iconhttp://orcid.org/0000-0003-2389-2833
ORCID Icon &
Zeliha SerindagDepartment of Internal Medicine, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey; ORCID Iconhttp://orcid.org/0000-0002-5919-8643
ORCID Icon show all
Pages 236-241 | Received 05 Nov 2019, Accepted 02 Jan 2020, Published online: 16 Jan 2020
 
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Abstract

Background: To investigate the protective efficacy of pentoxifylline through biochemical parameters and histopathological scores in a caerulein- and alcohol-induced experimental model of chronic pancreatitis in rats.

Methods: A model of chronic pancreatitis with caerulein and alcohol was created in female rats of the genus Sprague Dawley. Pentoxifylline was administered in doses of 25 mg/kg (low dose) and 50 mg/kg (high dose) as a protective agent. Each group contained 8 animals. The groups were: group 1 (control group); caerulein + alcohol, group 2 (low-dose pentoxifylline group); caerulein + alcohol + pentoxifylline 25 mg/kg, group 3 (high-dose pentoxifylline group); caerulein + alcohol + pentoxifylline 50 mg/kg, group 4 (placebo); caerulein + alcohol + saline, group 5 (sham group); only saline injection.Rats were sacrificed 12 h after the last injection, and TNF-α, TGF-β, MDA, and GPx concentrations were measured in blood samples. The histopathologic examination was conducted by a pathologist who was unaware of the groups.

Results: The biochemical results of the treatment groups (group 2 and group 3) were statistically significantly lower compared with the control group (group 1) (p < .05). The difference between the low-dose treatment group (group 2) and high-dose treatment group (group 3) was significant in terms of biochemical parameters (p < .05). The difference between group 2 and the control group was not significant in terms of histopathologic scores (p > .05), whereas the difference between the group 3 and the control group was statistically significant (p < .05).

Conclusions: As a result, pentoxifylline, which has anti-inflammatory and antioxidant properties, was shown to have protective efficacy in an experimentally generated model of chronic pancreatitis.

Disclosure statement

No potential conflict of interest was reported by the authors.

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