Abstract
Background
Colon Capsule Cleansing Assessment and Report (CC-CLEAR) is a novel quantitative bowel preparation scale for colon capsule.
Aim
The aim of this study is to validate the association between CC-CLEAR’s classification and major CC outcomes: lesion detection rate, surveillance recommendations and post-CC endoscopic treatment.
Methods
Multicentric cohort of consecutive CCs. An expert’s panel decided post-CC recommendations. Data included CC-CLEAR and Leighton-REX scales. Major CC outcomes were associated with the different cleansing grades.
Results
From 168 CC’s included, findings were reported in 123 (73.2%), 67 (54.4%) of those being colorectal polyps. CC-CLEAR influenced CC’s lesion detection (OR 1.25 95% IC [1.07–1.46], p-value .004) and polyp detection rate (OR 1.22 95% IC [1.04–1.43], p-value.014). Thirty-two (19%) post-CC colonoscopies were recommended, including 22 (68.75%) with at least one polypectomy. CC-CLEAR was associated with post-CC colonoscopy treatment (OR 1.40 95% IC [1.07–1.84], p-value .015). Regarding surveillance, CC-CLEAR influenced the decision for immediate CC repetition (OR 0.21 95% IC [0.12–0.36], p-value < .001) and the recommendation for CC in 3–5 years’ time (OR 1.47 95% IC [1.50–1.86], p-value < .002). The Leighton–Rex scale was not correlated with major CC outcomes.
Conclusion
CC-CLEAR impacts major CC outcomes: lesion detection, surveillance recommendations and post-CC endoscopic treatment.
Graphical Abstract
![](/cms/asset/55b56e5b-c57b-497f-948b-2f5232eebb2f/igas_a_2026463_uf0001_c.jpg)
Disclosure statement
The authors report there are no competing interests to declare.