Paraduodenal pancreatitis – problem in the groove

Abstract

Background

Paraduodenal pancreatitis (PDP) is a particular form of chronic pancreatitis (CP) occurring in and around the duodenal wall. Despite its low prevalence, this rare condition presents a significant challenge in clinical practice.

Methods

We retrospectively analysed the electronic medical charts of all patients with a diagnosis of chronic pancreatitis and identified those with PDP, between January 1999 and December 2020.

Results

There were 35 patients diagnosed with PDP (86% males and 14% females); median age of 56 ± 11 (range 38–80). Alcohol overconsumption was reported in 81% and smoking in 90% of patients. Abdominal pain was the leading symptom (71%), followed by weight loss, nausea and vomiting, jaundice, and diarrhoea. In 23 patients (66%), recurrent acute pancreatitis attacks were noted. Focal duodenal wall thickening was present in 34 patients (97%), cystic lesions in 80%, pancreatic duct dilatation in 54% and common bile duct dilatation in 46%. Endoscopic treatment was performed on nine patients (26%) and five patients (14%) underwent surgery. Complete symptom relief was reported in 12 patients (34%), partial symptom relief in three (9%), there was no improvement in five (14%), data were not available in three (9%) and 12 (34%) patients died before data analysis.

Conclusions

PDP is a rare form of pancreatitis, most commonly occurring in the 5th or 6th decade of life, with a predominance in males and patients with a history of smoking and high alcohol consumption. Focal thickening and cystic lesions of the duodenal wall are the most common imaging findings, followed by pancreatic duct and common bile duct dilatation. A minority of patients requires surgery.

Keywords:

• Paraduodenal pancreatitis
• groove pancreatitis
• cystic dystrophy of heterotopic pancreas
• duodenal dystrophy
• paraduodenal wall cyst

Disclosure statement

MV: Abbott (lecture fee), Mylan (lecture fee); JML: Abbott (lecture fee), Mylan (lecture fee)

MV: Swedish Magtarmfondens stipendium for research; Ruth and Richard Julin Foundation for research (not related to the present study); Guarantor of the article: MV, JML; All authors approved the final version of the article, including the authorship list.