Abstract
Background and objective
National patient registers are valuable in epidemiological studies. To ensure high-quality data for studies of irritable bowel syndrome (IBS), this study aimed to validate the ICD-10 code for IBS in the Swedish National Patient Register.
Methods
The positive predictive values (PPV) for IBS defined by the Rome criteria were calculated based on a review of medical records of randomly selected individuals with a first-ever diagnostic listing of IBS in the Swedish National Patient register in the year 2005 (Rome II criteria) or 2010 (Rome III criteria).
Key results
340 medical records were reviewed (172 from 2005 and 168 from 2010). The majority of patients were females (74%), and the mean age was 42 years. IBS used in any type of department had a PPV of 76% (95% confidence interval 71–80%), which increased to 80% (76–84%) when we included individuals likely to have IBS but where information about some aspects of the Rome criteria was lacking in the medical record. Two highly specialized gastroenterological departments had the best PPV, 96%, while departments of internal medicine in general had a PPV of 82% (80–95%). The PPV for the IBS subtype was 62% (55–67%). The PPVs were not significantly different comparing the two time periods investigated.
Conclusion and inferences
The validity of a register-based definition of IBS in the Swedish National Patient register is high and can be used to identify patients with IBS in observational research. The data source, i.e., type of hospital and department, influences reliability.
Acknowledgements
We want to acknowledge Dr. Paul Blomquist who passed away too early, who provided the idea for this study.
Author contributions
OO, HT, A-SB, MA, ML, and MS designed the study. NT created and analyzed the dataset. NT and HT wrote the manuscript which was critically revised and approved by OO, A-SB, MA, ML and MS. The final version of the manuscript was approved by all authors.
Disclosure statement
HT has served as an advisory board member/consultant and/or speaker for Takeda, Tillotts, Biocodex, Dr Falk Pharma GmbH. MS has received unrestricted research grants from Glycom, and served as an advisory board member/consultant and/or speaker for Danone Nutricia Research, Ironwood, Menarini, Biocodex, Genetic Analysis AS, DSM, Tillotts, Takeda, Arena, Kyowa Kirin, Adnovate, Atnahs Pharma, Takeda, AlfaSigma, Sanofi, Janssen Immunology, Pfizer, Ferrer, and Falk Foundation.