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Scandinavian Journal of Infectious Diseases Volume 39, 2007 - Issue 1
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CASE REPORT

Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: Successful combination therapy with voriconazole and terbinafine

Sunil V. Bhat From the Division of Infectious Diseases, The University of Pittsburgh Medical Center, Pittsburgh, PennsylvaniaCorrespondence[email protected]
,
David L. Paterson From the Division of Infectious Diseases, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
,
Michael G. Rinaldi Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
&
Peter J. Veldkamp From the Division of Infectious Diseases, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Pages 87-90 | Received 25 Apr 2006, Published online: 08 Jul 2009
 
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Abstract

A patient with chronic granulomatous disease developed brain abscesses with Scedosporium prolificans. In vitro susceptibility revealed a synergistic effect of terbinafine and voriconazole. He received therapy with both these antifungals which resulted in disappearance of the brain abscesses. This is the first reported cure of a CNS S. prolificans infection in an immunocompromised host.

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