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Scandinavian Journal of Infectious Diseases Volume 40, 2008 - Issue 8
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Original Article

Influence of chemotherapy courses on the rate of bloodstream infections during neutropenia in adult acute myeloid leukaemia

Urpo Kinnunen From the Department of Internal Medicine, Lapland Central Hospital, RovaniemiCorrespondence[email protected]
,
Pirjo Koistinen Departments of Internal Medicine,
,
Pasi Ohtonen Departments of Anaesthesiology and Surgery, Oulu University Hospital, Oulu, Finland
,
Markku Koskela Clinical Microbiology Laboratory,
&
Hannu Syrjälä Infection Control,
Pages 642-647 | Received 11 Sep 2007, Published online: 08 Jul 2009
 
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Abstract

To evaluate the effect of various chemotherapy courses on the rate of bloodstream infections (BSI) during therapy-related neutropenia, all infection episodes of adult patients with acute myeloid leukaemia (AML) during 7 y were retrospectively analysed in a university hospital. Of the 182 infection episodes in 76 AML patients, 37% (n=68) were BSI. The risk ratio (RR) of BSI was highest after regimens containing high-dose cytarabine (2.4 with 95% confidence interval (CI) 1.3–4.4) and lowest after thioguanine-containing courses (RR: 0.2, 95% CI 0.2–0.5). Chemotherapy courses per se may have an influence on the rate of BSI during neutropenia.

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