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Scandinavian Journal of Infectious Diseases Volume 40, 2008 - Issue 11-12
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Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity

José M. Miró From the Infectious Diseases Service, Microbiology Service,Correspondence[email protected]
,
Carlos Cervera From the Infectious Diseases Service, Microbiology Service,
,
Cristina García-de-la-Mària From the Infectious Diseases Service, Microbiology Service,
,
Ana Del Río From the Infectious Diseases Service, Microbiology Service,
,
Yolanda Armero From the Infectious Diseases Service, Microbiology Service,
,
Carlos A. Mestres Departments of Cardiovascular Surgery,
,
Jose M. Grau Internal Medicine, Hospital Clinic-IDIBAPSUniversity of Barcelona, Barcelona, Spain
,
Francesc Marco From the Infectious Diseases Service, Microbiology Service,
,
Asunción Moreno From the Infectious Diseases Service, Microbiology Service,
&
The Hospital Clinic Endocarditis Study Group From the Infectious Diseases Service, Microbiology Service,
 show all
Pages 968-972 | Received 25 Jun 2008, Published online: 08 Jul 2009
 
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Abstract

We report a patient with Enterococcus faecalis native-valve endocarditis who relapsed after 4 weeks of treatment with ampicillin plus gentamicin. The relapse was cured with ampicillin plus ceftriaxone, which was introduced after gentamicin-induced acute renal failure. This double beta-lactam combination showed a bactericidal effect in time-killing curve studies.

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