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Scandinavian Journal of Infectious Diseases Volume 41, 2009 - Issue 2
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Case Report

Pharmacokinetics and dialysate levels of daptomycin given intravenously in a peritoneal dialysis patient

Vega A. Goedecke From the Department of Internal Medicine, Division of Nephrology and Hypertension,
,
Christian Clajus From the Department of Internal Medicine, Division of Nephrology and Hypertension,
,
Olaf Burkhardt Department of Internal Medicine, Division of Pulmonary Medicine, Medical School Hannover, Hannover
,
Jens Martens-Lobenhoffer Institute for Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany
,
Stefanie M. Bode-Böger Institute for Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany
,
Jan T. Kielstein From the Department of Internal Medicine, Division of Nephrology and Hypertension,Correspondence[email protected]
&
Marcus Hiss From the Department of Internal Medicine, Division of Nephrology and Hypertension,
 show all
Pages 155-157 | Received 03 Nov 2006, Published online: 08 Jul 2009
 
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Abstract

In this report we present pharmacokinetic (Pk) data of daptomycin given intravenously in a peritoneal dialysis patient. Daptomycin plasma levels were within therapeutic range; however, half-life of the drug was prolonged compared to haemodialysis. Both plasma and dialysate levels were found to be consistently above the minimal inhibitory concentration for daptomycin sensitive strains.

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