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Abstract
Objective To verify the safety of desmopressin treatment and its associated side-effects in a large number of patients.Material and Methods The study was conducted in accordance with the guidelines of the Italian Club for Nocturnal Enuresis, whose criteria are: age >5 years; absence of malformations and infections of the urinary tract; absence of psychological disorders or neurological alterations; number of “wet nights” >5–7; control of liquid intake during the afternoon and evening; monitoring of serum electrolytes before beginning treatment; control of body weight before the beginning of treatment and during the first 4–5 days of therapy; and the informed consent of the parents. The therapeutic regimen provided for a maximum dose of desmopressin of 40 µg/day (four puffs/nostril or two tablets), starting from an initial dosage of 20 µg/day (two puffs/nostril or one tablet) 1 h before going to bed. The study involved two groups of patients with monosymptomatic enuresis: some of them had been administered desmopressin in the form of a spray and others in the form of tablets.Results A small percentage of patients presented mild, transient side-effects; in no case were severe side-effects verified.Conclusion Desmopressin is a safe drug with a low incidence of side-effects.