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Spectroscopy Letters
An International Journal for Rapid Communication
Volume 49, 2016 - Issue 6
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ORIGINAL ARTICLES

Calcium(II)–naproxen complex: Synthesis, characterization, and interaction with human serum albumin

Bin TangDepartment of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu, China
,
Jing WangDepartment of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu, China
,
Qing WangDepartment of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu, China
,
Ying XiaoDepartment of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu, China
,
Yanmei HuangDepartment of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu, China
,
Xiaoxiang LiaoDepartment of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu, China
&
Hui LiDepartment of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu, ChinaCorrespondence[email protected]
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Pages 404-412 | Received 10 Jan 2016, Accepted 31 Mar 2016, Published online: 11 Apr 2016
 
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ABSTRACT

A new calcium(II) complex with anti-inflammatory drug naproxen as ligand was synthesized and characterized. The binding mechanisms of calcium(II)–naproxen complex to human serum albumin (HSA) were investigated under simulative physiological conditions. The acting forces for the binding mechanisms were hydrogen bonds and van der Waals forces. Calcium(II)–naproxen complex and naproxen sodium may competitively bind to HSA at the same active Site I. Albumin binding weakened under the coexistence of the two substances. Thus, combining naproxen sodium and calcium(II)–naproxen complex may enhance treatment efficacy because of the synergistic effect.

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