https://orcid.org/0000-0002-9133-1037
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Abstract
In this study, silver nanoparticles-based surface-enhanced Raman spectroscopy combined with a serum protein purification method was employed to screen liver tumors. The cellulose acetate membrane was used to separate proteins from human serum, and then the purified serum proteins were mixed with silver nanoparticles for surface-enhanced Raman spectroscopy detection. High-quality spectra were recorded from serum protein samples belonging to 45 healthy volunteers and 42 liver cancer patients, and the diagnostic sensitivity and specificity of liver cancer were 90.5% and 95.6%, respectively, indicating that this method has great application potential for the detection and screening of liver cancer.
Additional information
Funding
This work was supported by the National Natural Science Foundation of China [61775037], Program for Changjiang Scholars and Innovative Research Team in University [IRT 15R10], Natural Science Foundation of Fujian Province of China [2019J01270, 2018J01876], Program for Supporting Research in Universities of Fujian Province [JK2017008], Special Funds of the Central Government Guiding Local Science and Technology Development [2020L3008], and the Open Project of Key Technology Platform of South China Normal University.