Photophysical properties of levofloxacin and norfloxacin drugs and their fluorescence quenching mechanism with caffeine

Abstract

Levofloxacin and norfloxacin are drugs used to treat various infections originating from bacterial species. In this research, the photophysical properties of the drugs were investigated using ultraviolet–visible absorption and fluorescence spectroscopic techniques. The results indicated the fluorescence quantum yields, lifetime, and non-radiative decay of the drugs are affected by solvent polarity and drug concentration. The binding mechanism of levofloxacin–caffeine and norfloxacin–caffeine were determined using the fluorescence quenching method. The quenching of drugs induced by caffeine is due to ground state complexes. The binding occurs spontaneously due to electrostatics, hydrogen and Van der Waals force play a major role in the reaction.

Keywords:

• Fluorescence quenching
• levofloxacin
• norfloxacin
• photophysical properties
• spectroscopy

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was supported by Adama Science and Technology University and Ministry of Innovation and Technology.

Notes on contributors

Kinfe Woldegiorges

All authors have contributed in designing the research. Kinfe Woldegiorges conducted the research, analyzed the data and wrote the manuscript. Abebe Belay and Alemu Kebede supervise the research work and reviewed the manuscript. All authors approved the final manuscript.

Abebe Belay

All authors have contributed in designing the research. Kinfe Woldegiorges conducted the research, analyzed the data and wrote the manuscript. Abebe Belay and Alemu Kebede supervise the research work and reviewed the manuscript. All authors approved the final manuscript.

Alemu Kebede

All authors have contributed in designing the research. Kinfe Woldegiorges conducted the research, analyzed the data and wrote the manuscript. Abebe Belay and Alemu Kebede supervise the research work and reviewed the manuscript. All authors approved the final manuscript.