The Second-Derivative Spectrophotometric Assay of a Multicomponent Analgetic Mixture

Abstract

In this paper the second-derivative spectrophotometric method for the simultaneous determination of some analgetic ingredients was described. Optimal conditions for the quantitative analysis of the three-component analgetic mixture of Dalivon® tablets were settled. The second-derivative order of the spectra in sodium hydroxide with the wavelength modulation was used. For the determination of paracetamol the “zero-crossing” technique was applied, but for propyphenazone and caffeine the characteristic peak amplitude had to be corrected.

The authors propose this second-derivative spectrophotometry for a rapid, simple, precise and accurate determination of the Dalivon® tablets or a corresponding multicomponent mixture.

Key Words:

• second-derivative spectrophotometry
• zero-crossing method
• method with correction
• paracetamol
• propyphenazone
• caffeine