Non-Invasive Thermometry in Hyperthermia by NMR Chemical Shift

Summary

The temperature dependence of the chemical shift for protons of CH2 groups franked to D2O was supported experimentally. The linear correlation between these parameters was established for all animal tissues examined in vivo.

The temperature coefficient of regression common for all the tissues: as found as a value of (0.01010±0.0042) ppm/°C. On the basis of these data it seems most interesting to use the changes of the chemical shift for protons of GH2 groups relative to D2O as a standard for detection and mapping of the spatial temperature distribution inside of biological systems.

This method may be found useful for hyperthermia and thermodiagnosis.