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Abstract
Celiprolol-hydrochloride has been determined using benzylorange and forming ion-pair. The absorbance of yellow coloured ion-pair is measured at 401 nm. Unknown concentrations of celiprolol-hydrochloride is calculated by using the calibration graph of the following calibration equation:
y = 0.1602 × + 0.0214
The conditional stability constant of the ion-pair at the optimum pH 6.2 and ionic strength 0.05 is found to be 5.63. The method is successfully applied to the determination of celiprolol-hydrochloride in pharmaceutical preparations.