Improved Experimental Procedure for the Synthesis of the Potent MEK Inhibitor PD184352

Abstract

An improved synthesis of the potent MEK inhibitor PD184352 (2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide)) is herein reported. This new and reproducible protocol provides a simple and efficient way of generating gram quantities of PD184352 with minimal purification.

Keywords:

• Inhibitor
• Hydroxylamines
• PD184352