Straightforward Synthesis of a Novel Maleimide‐DTPA Bifunctional Chelating Agent

Abstract

An extremely easy and multigram scale synthesis of a new maleimide‐DTPA derivative is described. This bifunctional chelating agent finds application in bioconjugate chemistry because the maleimido group allows easy labeling of thiol‐containing molecules (e.g., proteins, peptides) and the DTPA moiety ensures a strong and stable coordination of metal and radiometal ions such as gadolinium, lutetium, indium, and yttrium.

Keywords:

• Bifunctional chelating agent
• bioconjugate chemistry
• DTPA
• labeling
• maleimide linker
• thiol