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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 20
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Original Articles

New Approach for the Synthesis of N‐Indolyl Ketones and Aldehydes

Hua‐Sheng Ding State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai, China; Graduate School of the Chinese Academy of Science, Beijing, China
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Dr. Chun‐Hao Yang State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai, China; Graduate School of the Chinese Academy of Science, Beijing, ChinaCorrespondence[email protected]
&
Yu‐Yuan Xie State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai, China; Graduate School of the Chinese Academy of Science, Beijing, China
Pages 2625-2632 | Received 22 Mar 2005, Published online: 22 Aug 2006
 
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Abstract

A new approach for the synthesis of N‐indolyl ketones and aldehydes was developed. In the reaction of N‐indolyl carboxylic acids with alkyl lithium, an interesting phenomenon appeared when using THF as solvent instead of ethyl ether.

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