Synthesis and Biological Evaluation of Novel Isonucleosides with 1,2,4‐Triazole‐3‐Carboxamide

Abstract

Novel 1,2,4‐triazole isonucleosides (1 and 2) were efficiently synthesized starting from D‐ribose and D‐xylose, respectively. The key steps were condensation of cyclic sulfate 8 with methyl‐1,2,4‐triazole‐3‐carboxylate and nucleophilic displacement of the tosylate 15 with methyl‐1,2,4‐triazole‐3‐carboxylate, respectively.

Keywords:

• Antiviral agent
• IMPDH
• isonucleoside
• 1,2,4‐trizole

Acknowledgment

This work was supported by a postdoctoral fellowship from Korea Science & Engineering Foundation (KOSEF).