Synthesis of 4‐Methyl Pyrrolo[2,3‐b]xanthone, a Novel Ring System

Abstract

A short, high yielding synthesis of a novel substituted pyrrolo[2,3-b]xanthone has been developed. The synthesis begins with a copper catalyzed Ullmann coupling reaction followed by and intramolecular Friedel-Crafts acylation reaction to establish the xanthone core structure. After a regioselective nitration, a Leimgruber-Batcho synthesis establishes the final pyrrole ring.

Keywords:

• Ullman coupling reaction
• pyrrolo[2,3-b]xanthone
• Leimgruber-Batcho synthesis