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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 1
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Original Articles

Synthesis of Novel Norcantharidin Derivatives of Substituted Aromatic Amines with Improved 1,3‐Dipolar Cycloaddition

Liping Deng School of Pharmaceutical Science, Zhejiang University, Department of Medicinal Chemistry, Hangzhou, China
&
Yongzhou Hu School of Pharmaceutical Science, Zhejiang University, Department of Medicinal Chemistry, Hangzhou, ChinaCorrespondence[email protected]
Pages 157-163 | Published online: 25 Jul 2007
 
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Abstract

Fourteen novel compounds were synthesized in a single step in good yield by the [3+2] 1,3‐dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with nitrile oximes in the presence of chloramine‐T as compared to the conventional method.

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