Abstract
A neat and rapid procedure is reported for the synthesis of a variety of 2‐aryloxymethylene‐6‐arylimidazo[2,1‐b]‐1,3,4‐thiadiazole (3a–3r) by condensation reaction of 2‐amino‐5‐aryloxymethylene‐1,3,4‐thiadiazole (1a–1f) with ω‐bromoacetophenone (2a–2c) in ethanol solvent under microwave irradiation, which yielded a series of novel compounds. The yields are good to excellent. The procedure is simple and does not need any added catalyst or dehydrating reagent. Moreover, the crystals do not require further purification to give the products.
Acknowledgment
The authors thank the Scientific and Technological Innovation Engineering program of Northwest Normal University (NWNU‐KJCXGC‐02‐08), Natural Science Foundation of Gansu Province (ZS021‐A25‐006‐Z), and Environmental Protection Foundation of Gansu Province (GH2003‐19) for the financial support of this work.