Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 22
Submit an article Journal homepage
108
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Efficient One‐Step Synthesis of a Key Intermediate for the Synthesis of Azole Antifungals Using the Mitsunobu Protocol

Jitendra A. Sattigeri Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratory, Gurgaon, Haryana, India
,
Jasbir S. Arora Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratory, Gurgaon, Haryana, India
,
Ashwani K. Verma Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratory, Gurgaon, Haryana, India
,
Sanjay Malhotra Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratory, Gurgaon, Haryana, India
&
Mohammad Salman Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratory, Gurgaon, Haryana, IndiaCorrespondence[email protected]
Pages 2939-2943 | Received 13 May 2005, Published online: 22 Aug 2006
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

A simple and single‐step process for coupling (2R,1S)‐1‐[2‐(2,4‐difluorophenyl)‐2‐oxiranyl]ethanol and various 1,2,4‐triazolones utilizing the Mitsunobu protocol is described. The product so formed is a key intermediate in the synthesis of azole antifungals with potent and broad‐spectrum activity against yeast and filamentous fungi.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.