Convenient One‐Pot Heterogeneous Catalytic Method for the Preparation of 3,4‐Dihydropyrimidin‐2(1H)‐ones

Abstract

A new, simple, environmentally friendly synthesis of dihydropyrimidinones from aromatic and aliphatic aldehydes, ethyl acetoacetate, and urea or thiourea using a small‐pore‐size zeolite as catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of high yield, shorter reaction time, and recyclable and reusable catalyst.

Keywords:

• Biginelli reaction
• green chemistry
• heterocycles
• multicomponent reaction
• zeolites

Acknowledgments

This work was supported by the Hungarian Scientific Research Fund Programs (OTKA Grant No. T 037757).