Synthesis of 2‐Aminothiophenes on Ionic Liquid Phase Support using the Gewald Reaction

Abstract

The first report of the use of task‐specific ionic liquid as soluble support for the Gewald synthesis of 2‐aminothiophenes is reported in this article. This synthetic method is simple and efficient, and the products are obtained in good to excellent yields with high purities, without the need for chromatographic purification.

Keywords:

• 2‐Aminothiophene
• Gewald synthesis
• ionic liquids
• soluble support

Acknowledgments

This work is supported by the National Natural Sciences Foundation of China (No. 20336010), and the State Key Basic Research and Development Project of China (No. 2003CB716004).