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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 12
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Original Articles

Fragment Assembly: An Alternative Approach to Generating Complex Polyketides

Simon J. Shaw Kosan Biosciences, Hayward, California, USACorrespondence[email protected]
,
Dan Zhang Kosan Biosciences, Hayward, California, USA
,
Kurt F. Sundermann Kosan Biosciences, Hayward, California, USA
&
David C. Myles Kosan Biosciences, Hayward, California, USA
Pages 1735-1743 | Received 19 Dec 2005, Published online: 22 Aug 2006
 
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Abstract

A new approach to the preparation of complex polyketide natural products has been outlined in which the products of biosynthesis are used as starting materials for chemical synthesis of difficult‐to‐obtain natural products.

Acknowledgments

This work was partially supported by National Institutes of Health Small Business Innovative Research (NIH SBIR) Grant No. 5R44CA093408.

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