Simple Synthesis of Versatile Coumarin Scaffolds

Abstract

We describe an approach using ring‐closing metathesis (RCM) to synthesize versatile coumarin derivatives that present appropriate substitutions both at the aromatic and at the α,β‐unsaturated lactone ring. The obtained compounds can be used as molecular scaffolds suitable for further diversifications through a combinatorial approach.

Keywords:

• Coumarins
• lactones
• oxygen heterocycles
• ring‐closing metathesis

Acknowledgments

This research was financed in part by the Combigen Consortium.