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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 16
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Original Articles

Alternative Synthesis of 1,2,3,4‐Tetramethoxy‐5‐methylbenzene: A Key Intermediate for Preparing Coenzyme Q Homologs and Analogs

, &
Pages 2401-2405 | Received 24 Nov 2005, Published online: 22 Sep 2006
 

Abstract

Preparation of 1,2,3,4‐tetramethoxy‐5‐methylbenzene (1) through a new process from pyrogallol is described. In the preparation, a modified mild brominating agent was employed, and a simple introduction of methyl group into aromatic ring through chloromethylation of the corresponding substrate (4), followed by reductive dehalogenation, was achieved successfully with good yields.

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