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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 18
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Original Articles

Synthesis of Tadalafil Analogues

Liu‐Tang Wang West China School of Pharmacy, Sichuan University, Chengdu, China
,
Hao Huang Chengdu College of Education, Chengdu, China
,
Zhong‐Lin Ye Department of Research and Development Di'ao Co. Ltd, Chengdu, China
,
Yong Wu West China School of Pharmacy, Sichuan University, Chengdu, China
&
Xue‐Chao Wang Department of Research and Development Di'ao Co. Ltd, Chengdu, China
Pages 2627-2632 | Published online: 16 Feb 2007
 
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Abstract

Five novel compounds as potential phosphodiesterase type 5 (PDE‐5) inhibitors were synthesized from D‐tryptophan methyl ester via the Pictet–Spengler reaction and cyclization reaction. The structures of those compounds were confirmed by elemental analyses, IR, 1H NMR, and ESI‐MS spectra.

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