Chemoselective and Solvent‐Free Thioacetalization of Aldehydes by a Catalytic Amount of NBS

Abstract

A chemoselective, straightforward, and rapid method for thioacetalization of aldehydes by use of 1,2‐ethandithiol and a catalytic amount of N‐bromosuccinimide under solvent‐free conditions is reported. The reaction takes place in excellent yields and short reaction times.

Keywords:

• Thioacetalization
• NBS
• solvent‐free
• chemoselective
• aldehydes

Acknowledgments

We gratefully acknowledge the funding support received for this project from the Isfahan University of Technology (IUT), I.R. Iran (A. R. H.) and Grants GM 033138, MH 065503, NS 033650 (A. E. R.) from the National Institutes of Health, USA. Further financial support from Center of Excellence in Chemistry Research (IUT) is gratefully acknowledged.