Efficient Room‐Temperature Synthesis of Tri‐ and Tetrasubstituted Imidazoles Catalyzed by ZrCl₄

Abstract

A general protocol has been developed for the rapid synthesis of 2,4,5‐trisubstituted and 1,2,4,5‐tetrasubstituted imidazoles in high yields using ZrCl₄ as an efficient catalyst at room temperature. A variety of aromatic, aliphatic, and terpenoidal aldehydes underwent condensation with NH₄OAc/amines to give the imidazoles. Similarly, the imidazole glycoconjugates are prepared in good yields from the corresponding glycosyl aldehydes.

IICT Communication No. 051119.

Keywords:

• 1,2‐Diarylethanedienones
• imidazole glycoconjugates
• three/four‐component coupling reaction
• tri/tetrasubstituted imidazoles

Acknowledgments

Y. J. and P. S. L. acknowledge the Council of Scientific and Industrial Research (CSIR), New Delhi, India, for financial support.

Notes

IICT Communication No. 051119.