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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 17
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Original Articles

Efficient Synthesis of Pyridylacrylonitriles via the Heck Reaction

Kui Mei College of Pharmacy, Wuhan University, Wuhan, China
,
Junbo Wang Sundia Meditech Company Ltd., Shanghai, China
&
Xianming Hu College of Pharmacy, Wuhan University, Wuhan, ChinaCorrespondence[email protected]
Pages 2525-2532 | Received 02 Aug 2005, Published online: 27 Oct 2006
 
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Abstract

A new synthetic pathway to pyridylacrylonitriles has been developed based on a palladium‐catalyzed Heck reaction. The optimized process and the preparation of related functionalized pyridylacrylonitriles are discussed.

Acknowledgment

We are grateful for the financial support from Sundia Meditech Company Ltd., Shanghai, China, and technical advice from its scientific staff.

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