Novel Traceless Liquid‐Phase Synthesis of Coumarin Derivatives on Poly(Ethylene Glycol) Support

Abstract

Coumarin derivatives were prepared by the von Pechmann reaction of PEG‐bound acetoacetate reagent with phenols in the presence of TiCl₄ in excellent yield and purity with a facile workup procedure. The polymer reagent could be recycled two to four times without diminishing the yield or purity.

Keywords:

• Coumarins
• liquid‐phase synthesis
• PEG‐bound acetoacetate
• von Pechmann reaction

Acknowledgment

We gratefully acknowledge financial support from the National Natural Science Foundation (NSF) of China (No. 20562005) and NSF of Jiangxi Province (No. 0620021).