Synthesis and Characterization of Benzenesulfonyl Hydrazones and Benzenesulfonamides

Abstract

In the search for structural cyclic imide analogues of therapeutic interest, the syntheses and characterization of benzenesulfonyl hydrazones and benzenesulfonamides are described. The benzenesulfonyl chlorides (2) and (3) were obtained through the Diels–Alder reaction between N‐p‐chloro‐sulfonylfenylmaleimide (1) and furan or 2‐methylfuran. The reactions of (2) and (3) with hydrazine and amines afforded the hydrazides and sulfonamides, respectively. The sulfonylhydrazones were obtained through a condensation between the sulfonylhydrazides with different benzaldehydes.

Keywords:

• Benzenesulfonyl chlorides
• Diels–Alder reaction
• sulfonamides
• sulfonylhydrazones

Acknowledgments

The authors are grateful to CNPq for financial support of this work.