Regioselective N‐Arylation of Some Pyrimidine and Purine Nucleobases

Abstract

N‐Arylation of some pyrimidine and purine nucleobases in the presence of SiO₂ and Cs₂CO₃ under solvent‐free as well as in solution conditions is described. In these conditions, N1‐aryl pyrimidines and N9‐aryl purines have been obtained regioselectively in moderate to high yields with relatively short reaction times.

Keywords:

• N‐arylation
• nucleobase
• purine
• pyrimidine
• SN_Ar

Acknowledgments

We thank the Shiraz University and Shiraz University of Technology Research Councils for financial support of this work. We are also grateful to H. Sharghi for helpful discussion, and H. Sajedian Fard for running the NMR spectra.