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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 23
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Original Articles

Rapid Synthesis of New 5‐Nitroimidazoles as Potential Antibacterial Drugs via VNS Procedure

Maxime D. Crozet Laboratory of Pharmaceutical Organic Chemistry, UMR–CNRS 6517, Faculty of Pharmacy, Marseille, France
,
Vincent Rémusat Laboratory of Pharmaceutical Organic Chemistry, UMR–CNRS 6517, Faculty of Pharmacy, Marseille, France
,
Christophe Curti Laboratory of Pharmaceutical Organic Chemistry, UMR–CNRS 6517, Faculty of Pharmacy, Marseille, France
&
Patrice Vanelle Laboratory of Pharmaceutical Organic Chemistry, UMR–CNRS 6517, Faculty of Pharmacy, Marseille, FranceCorrespondence[email protected]
Pages 3639-3646 | Received 02 Feb 2006, Published online: 24 Nov 2006
 
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Abstract

Original 4‐arylsulfonylmethyl‐5‐nitroimidazoles were prepared by reacting four chloromethylaryl sulfones with 5‐nitroimidazole derivatives via a vicarious nucleophilic substitution (VNS) of hydrogen reaction.

Acknowledgments

This work has been supported by the Centre National de la Recherche Scientifique and the Universities of Aix‐Marseille. Authors thank C. Chapuis for technical support.

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