Abstract
β‐Secretase inhibitors with a Leu*Ala hydroxyethylene dipeptide (HED) isostere have been an especially interesting topic in recent years. In this study, a template compound 17 was synthesized, featuring truncation at the P2′ position and changes at P2 and P3, which differs from other reported potent inhibitors. The purpose was to explore optimal reaction conditions and construct an inhibitor library to investigate ideal protein–substrate interaction.
Acknowledgment
This work was supported by the National Natural Science Foundation of China (Nos. 20272004 and 20572006) and the 985 program, Ministry of Education of China.