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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 3
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Original Articles

Application of Polymer‐Supported Triphenylphosphine and Microwave Irradiation to the Palladium‐Catalyzed Cyanation of Aryl Triflates

Rajiv R. Srivastava Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USACorrespondence[email protected]
,
Andrew J. Zych Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USA
,
David M. Jenkins Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USA
,
Hong‐Jun Wang Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USA
,
Zhen‐Jia Chen, Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USA
&
David J. Fairfax Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USA
Pages 431-438 | Received 19 Feb 2006, Published online: 06 Feb 2007
 
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Abstract

A variety of aryl nitriles were prepared in excellent yield from the palladium(II) acetate–catalyzed cross‐coupling of aryl triflates and zinc cyanide under microwave irradiation conditions. To facilitate purification, polymer‐supported triphenylphosphine was used as the palladium ligand. Comparison to the corresponding thermal conditions revealed much shorter reaction times with comparable yields.

Acknowledgments

The authors thank Brian T. Gregg and William G. Earley for helpful discussions.

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